Semaglutide dosage chart
Same structure as the tirzepatide chart, smaller numbers, and one extra way
to get it wrong: semaglutide doses are small enough that a bad concentration puts your dose
down at the fiddly end of the barrel.
The schedule
Standard titration for semaglutide. Four weeks per step. Wegovy (weight) tops out
at 2.4 mg; Ozempic (diabetes) at 2 mg.
| When | Dose | What it's for |
|---|
| Weeks 1–4 | 0.25 mg | Starting dose. Does almost nothing except let your gut adjust. |
| Weeks 5–8 | 0.5 mg | First dose that does real work. |
| Weeks 9–12 | 1 mg | Ozempic often stops here. |
| Weeks 13–16 | 1.7 mg | Wegovy only. Ozempic goes 1 → 2 instead. |
| Week 17+ | 2.4 mg | Wegovy maintenance. The top of the ladder. |
The same schedule, in units
Units on a U-100 syringe. Red on the right means it won't fit in one syringe; red
on the left means it's too small a draw to hit accurately.
| Dose | 1 mg/mL | 2.5 mg/mL | 5 mg/mL | 10 mg/mL |
|---|
| 0.25 mg | 25 | 10 | 5 | 2.5 |
| 0.5 mg | 50 | 20 | 10 | 5 |
| 1 mg | 100 | 40 | 20 | 10 |
| 1.7 mg | 170 ✗ | 68 | 34 | 17 |
| 2.4 mg | 240 ✗ | 96 | 48 | 24 |
2.5 mg/mL is the column with no red in it. At 1 mg/mL the top two doses overflow the
syringe. At 10 mg/mL your first month is a 2.5-unit draw, which is a sliver of liquid barely
off the hub. At 2.5 mg/mL every dose in the whole schedule lands somewhere you can actually
see and hit. If your pharmacy lets you choose, that's the one to choose.
Your vial
Common setups:
Semaglutide is not tirzepatide
They get talked about interchangeably and they are not interchangeable. Different
molecules, different ladders, doses an order of magnitude apart. 2.4 mg is a full
semaglutide dose and a rounding error of a tirzepatide one.
Which matters if you switch. People move between them fairly often — tolerance, supply,
price — and the instinct to keep drawing the same number of units is exactly the wrong one.
New drug, new vial, new concentration, new arithmetic. Do the whole thing again from the
label.
| Semaglutide | Tirzepatide |
|---|
| Starting dose | 0.25 mg | 2.5 mg |
| Maximum | 2.4 mg | 15 mg |
| Steps to the top | 5 | 6 |
| Receptors it works on | GLP-1 | GLP-1 + GIP |